IL-21 Limits NK Cell Responses and Promotes Antigen-Specific T Cell Activation

NK T cell activation promotes Chlamydia trachomatis infection in vivo.

We used two approaches to examine the role of NK T cells (NKT) in an intracellular bacterial (Chlamydia trachomatis mouse pneumonitis (C. muridarum)) infection. One is to use CD1 gene knockout (KO) mice, which lack NKT, and the other is to activate NKT using alpha-galactosylceramide (alpha-GalCer), a natural ligand of these cells. The data showed a promoting effect of NKT activation on Chlamydi...

Cell Response and Affinity of the Antigen-specific Cd8 T Il-21 Influences the Frequency, Phenotype

Interleukin-21 Enhances NK Cell Activation

Stepwise phosphorylation of p65 promotes NF-κB activation and NK cell responses during target cell recognition

NF-κB is a key transcription factor that dictates the outcome of diverse immune responses. How NF-κB is regulated by multiple activating receptors that are engaged during natural killer (NK)-target cell contact remains undefined. Here we show that sole engagement of NKG2D, 2B4 or DNAM-1 is insufficient for NF-κB activation. Rather, cooperation between these receptors is required at the level of...

NK-cell-mediated killing of target cells triggers robust antigen-specific T-cell-mediated and humoral responses.

Previous work showed that administration of antigen-expressing apoptotic cells in vivo results in antigen-specific CD8+ T-cell responses independent of Toll-like receptor signaling. We report here that natural killer (NK) cells can serve a function directly upstream of this pathway and initiate robust adaptive immune responses via killing of antigen-expressing target cells. This pathway is high...